Reaching the New Heights of Breath

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A person who reaches a plateau 3,000 meters above sea level is exposed to a low pressure, low oxygen environment. This will cause him to suffer from various discomforts due to altitude sickness, such as headaches, palpitations, insomnia, fatigue, and dyspnea, all of which place a heavy burden on the cardiopulmonary system. People who live on the plateau for a long time will have cardiopulmonary diseases that are different from those of the plains. Naqu, China and El Alto-La Paz, Bolivia are situated at opposite ends of the globe in terms of latitude and longitude. But they are both located on plateaus with extremely high altitudes and faced with very similar medical challenges.

Located in the hinterland of China's Qinghai-Tibet Plateau, Naqu's climate is chilly, low on oxygen, and predominantly dry, with about 100 windy days a year. It is also the source of the Yangtze and Nujiang Rivers, among others. Due to the lack of heat and water required for vegetation to grow, lush forests are rarely seen across this vast landscape, where the air only has half the oxygen content compared with at sea level. As one of the largest pastures in China, it's home to generations of herders.

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Average altitude

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Average altitude

Thanks to the economic growth and improvements in transportation, Naqu Town, once a sparsely populated village, has now grown into a thriving transportation and economic hub. However, its infrastructure is still lagging behind areas with lower altitudes due to the harsh environment, and unfortunately, rapid population growth is putting pressure on its healthcare system. In the event that a ventilator fails, the service staff have to make an arduous journey to get a new one, which demands a lot of manpower and time. Medical professionals do not get the equipment and supplies they need in a timely and effective manner, leading to delays in patient treatment.

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Average altitude of Naqu

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Population of Naqu

1 km2

Land area of Naqu

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Natural population growth rate

Common lung diseases in Naqu:
Tuberculosis, pneumonia, asthma, and lung cancer

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Altitude of El Alto

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Altitude of La Paz

El Alto-La Paz is located in the eastern part of the Bolivian Altiplano. Las Paz is the highest capital city in the world. Owing to its high altitude, it enjoys an unusual subtropical highland climate with rainy summers and dry winters. La Paz is an important political, administrative, economic, and sporting center of Bolivia, as well as a cultural city in Latin America, with a rich and diverse historical heritage left over from the colonial period. El Alto is the second largest city in Bolivia and the highest major city in the world. The metropolitan area has an unusual subtropical plateau climate with rainy summers and dry winters. In spite of its high altitude, the majority of Bolivians still choose to live in El Alto-La Paz where the economy is booming.

1.1 million

Population of metropolitan area

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Altitude of La Paz

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Altitude of El Alto

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Percentage of population that is undernourished in Bolivia

1.3 %

Percentage of Bolivia's GDP spent on
healthcare (2018 data)

Diseases with the highest mortality rate in Bolivia: Coronary heart disease, lower respiratory tract infection, stroke

Bolivia has vigorously reformed its healthcare system in recent years, but overall it still lags behind most countries in Latin America. In 2019, there was only one doctor for every 1,000 residents. This shortage of medical professionals combined with a lack of professional health knowledge and a weak healthcare system meant Bolivia was severely hit by COVID-19. As Bolivia’s second largest metropolitan area, El Alto-La Paz bears responsibility for providing medical care for both the local and national population. In the post-pandemic era, there is an urgent need for ventilators that are reliable and easy to use. In fact, it can be a matter of life or death for residents on the plateau.

Bringing Mindray ventilators to the highland

Mindray's R&D team took into account all the factors that could affect the ventilator in the process of research and development. In the face of the harsh plateau environment, the team analyzed its impact on the ventilator's materials and specification requirements for key components (valves, turbines, sensors), the key algorithm control performance, monitoring performance, maintenance of the system, and its alarms (such as air pressure and temperature changes, oxygen concentration monitoring, the gas output of the turbine).

Turbine optimization

The turbine is the power source for the flow and pressure outputs of the ventilator. The outputs are influenced by altitude, as the air becomes thinner higher up. As a therapeutic medical device, ventilators need to be reliable to prevent patients' conditions from deteriorating. This means that the rated output of the turbine needs to be turned up for ventilation at higher altitudes. But this leads to another problem: the heat caused by the increased power will shorten the service life of the turbine. To this end, by simulating different altitude environments, output pressures, turbine speeds, and temperatures, Mindray's R&D team finally succeeded in using active heat sinks to dissipate heat from the turbine, extending the service life of the turbine while ensuring reliable performance.

Altitude compensation

The monitoring of ventilator parameters plays an integral role in guaranteeing a patient's safety, and the monitoring of both tidal volume and oxygen concentration can be affected by high altitudes. Compared with areas at low altitude, the ventilator sensor can deviate by more than half in a low pressure environment at high altitude. This will cause high risks and non-controllability in therapeutic devices such as ventilators. To ensure an accurate monitoring of tidal volume and oxygen concentration, the R&D team set up an altitude compensation algorithm, enabling accurate gas delivery for patients. In view of the importance of altitude compensation, the R&D team set up dual atmospheric pressure sensors to optimize the monitoring of the ventilator at high altitudes. This means monitoring data can be backed up for mutual inspection and the altitude can be automatically calculated by the monitored atmospheric pressure, which ultimately ensures the accuracy and safety of altitude monitoring.

Simulation test

After designing and developing the ventilator adapted to high altitudes, the R&D team fully simulated and tested it in low-temperature and low-pressure environments to ensure it met the specifications and performance requirements. The device was able to work normally and meet clinical requirements at an altitude of up to 5,000 meters. And a ventilator that could function properly on high-altitude plateaus was born.

Delivering technology the final mile

Located in Seni District, Naqu City, Nagqu People's Hospital is the only Grade A tertiary hospital in northern Tibet that integrates medical treatment, emergency care, prevention, health care, scientific research, and teaching. It is a lifeline for the 500,000 local residents.

The ICU of Nagqu People's Hospital is regarded as the highest ICU in the world, providing timely treatment for critically ill patients on the plateau. I have seen great improvements in our hospital's medical facilities and capabilities since joining it in 2013. Mindray's medical devices in our ICU fully embrace the potential of the latest technology. They significantly optimize workflows, keeping me updated with intelligent, automated, and remote operations.

Multiple traumas from car accidents, lightning, and even bear scratches are typically seen in critical patients on the Naqu plateau due to its unique natural environment. The golden hour for treatment is often missed as it may take hours to get to a hospital that can perform surgery. The ICU department is now able to use Mindray's high-performance ventilators to provide effective and timely ventilation support for patients with multiple traumas, cranio-cerebral injuries, acute plateau reactions, and severe infections.

I have only been using Mindray's ventilators for three years due to the limited medical supplies here, however, they have really impressed me with outstanding performance in rescuing critically ill patients. Mindray's clinical experts and service engineers provide regular training for our medical staff, which gives me many professional skills too.

Our emergency departments are equipped with two of Mindray's SV series ventilators that boast a simple interface design and quick ventilation, enabling us to act and make decisions with ease in emergency cases. I am looking forward to further cooperation between our departments and Mindray in the field of interconnectivity of emergency devices.

It usually takes several hours to drive along rural roads to county hospitals in Nagqu to install devices there and explain how to use them. It is quite a long and arduous journey, and often interrupted by bad weather and road conditions. We make sure to check on local road information in real time and plan our routes carefully so that each trip covers as many hospitals as possible. Prior to the availability of social media and Mindray's IT solutions, we had to do device maintenance on site. Now, by providing remote guidance via cloud video, we can handle urgent issues in a more timely manner.

Faced with the potential risk of altitude sickness, we often dispatch teams in which each member is able to carry out multiple jobs and work collaboratively, with the same goal of efficiently completing the mission and returning to lower altitudes as soon as possible. While training the local medical staff, I would forget all the uncomfortable symptoms, such as headaches and dyspnea caused by altitude sickness. The doctors and nurses listened attentively and were constantly amazed that Mindray's machines could work properly and continuously at such a high altitude. I am so proud to be able to contribute to medical care on the harsh plateau.

Villa Dolores Hospital is located in El Alto, 4150 meters above sea level. The hospital currently has 60 beds, including 13 ICU beds. As a level 3 hospital by Bolivian hospital standards, Villa Dolores is committed to providing timely and reliable care for patients in the region.

Our hospital is on a plateau of more than 4,000 meters, and requires high equipment stability and safety. Since we started collaboration 6 years ago, Mindray’s devices have been stable and reliable, and there has never been any failure, saving a lot of lives. We are very satisfied.

La Paz and the neighboring El Alto are located high in the mountains, with rugged and narrow streets and traffic congestion that needs to be relieved by cable cars. On the way to visit hospitals, the mountain roads are winding and undulating, and the drop of tens or even hundreds of meters places great demands on the transportation of vehicles and devices. We came here from a low-altitude area, and since our body cannot adapt to the plateau quickly, it takes a long time for us to say a word when communicating and training with medical staff. However, with excellent equipment and professional services, we have successfully won the trust of partner hospitals. Up to now, we have installed Mindray SV Series Ventilators in 70% of clinics and 30% of level 2 and level 3 hospitals in Bolivia.

Mindray is committed to bringing high-quality care to every corner of the world. Whether Naqu or El Alto-La Paz, we always align with our customers and strive to develop medical technology that can be successfully adapted to local environments.

In addition to providing devices, we pay extra attention to the special needs of healthcare professionals in remote areas for services and training. We make full use of online and offline channels to provide local medical staff with comprehensive, professional and detailed training and user services.

As we bring breath to new heights, there is warmth in places high and cold.